Cryptococcus neoformans WD40 Phenome Database

Welcome to the WD40 Phenome knowledgebase

Browse WD40 domain-containing genes and explore functional phenotypic data from gene knockout and CTR4 conditional knockdown experiments.

Search WD40

Provide locus name, for example CNAG_00073, or part of it.

Cryptococcus neoformans WD40 Phenome Database abstract
WD40 genes × phenotypic assay

Browse WD40 genes

A total 89 WD40 domain-containing genes in serotype A Cryptococcus neoformans var. grubii, identified using WDSPdb and validated using InterPro, are archived in the database.

Browse genes

Phenotype database

Functional phenotypic traits under multiple growth conditions are available for 53 knockout mutants and 36 CTR4 conditional knockdown strains, based on RNA-seq analyses.

Functional annotation

Each entry provides detailed annotations such as Pfam and KEGG orthology. Integrated JBrowse and ProteinPlus links enable contextual visualization of genomic loci, expression profiles, and protein interaction potential.

Structural insights

Explore AlphaFold-predicted 3D structures with WD40 domains highlighted. WD40 domains are annotated using HMMsearch against the Pfam database (PF00400.38; canonical WD40).

WD40 structure

About the resource

From annotation to phenotype.

This database integrates WD40 domain annotation and phenotype data for Cryptococcus neoformans. Each entry provides multiple links to gene details and associated experimental results.

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